5-Hydroxyindoleacetic Acid, 24 Hour, Urine

Additional Codes

Mayo Test Code: HIAA

Reporting Name

5-Hydroxyindoleacetic Acid, U

Useful For

Biochemical diagnosis and monitoring of intestinal carcinoid syndrome

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine

Necessary Information

24-hour volume is required.

Specimen Required

Patient Preparation:

1. Some medications could interfere with test results. The ordering provider should decide if any medications should be stopped and when they should be restarted. If clinically feasible, discontinue the following medications at least 48 hours prior to, as well as during, specimen collection:

-Acetaminophen (Tylenol or generic versions)

-Aspirin

-Antihistamines

-Cough syrups

-Cold and flu medications

2. For 48 hours prior to, as well as during, the urine collection, the patient should:

Limit the following to 1 serving per day:

-Fruits

-Vegetables

-Nuts

-Caffeinated beverages or foods

Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a 24-hour urine specimen.

2. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children <5 years old.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type	Temperature	Time	Special Container
Urine	Refrigerated (preferred)	56 days
	Frozen	365 days

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Special Instructions

Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens

Reference Values

	5HIAA, mg/24 hour 99th percentile cutoff
Age	Female	Male
≤23 months	≤2.7	≤2.3
24-35 months	≤3.0	≤2.6
3 years	≤3.2	≤2.9
4 years	≤3.4	≤3.2
5 years	≤3.6	≤3.6
6 years	≤3.8	≤3.9
7 years	≤4.0	≤4.2
8 years	≤4.2	≤4.5
9 years	≤4.5	≤4.8
10 years	≤4.7	≤5.1
11 years	≤4.9	≤5.3
12 years	≤5.2	≤5.6
13 years	≤5.4	≤5.8
14 years	≤5.6	≤6.1
15 years	≤5.7	≤6.3
16 years	≤5.9	≤6.4
17 years	≤6.0	≤6.6
18 years	≤6.0	≤6.7
19 years	≤6.1	≤6.8
20 years	≤6.1	≤6.9
21 years	≤6.2	≤6.9
22 years	≤6.2	≤7.0
23 years	≤6.2	≤7.0
24 years	≤6.3	≤7.1
25 years	≤6.3	≤7.2
26 years	≤6.3	≤7.2
27 years	≤6.4	≤7.3
28 years	≤6.4	≤7.4
29 years	≤6.5	≤7.5
30 years	≤6.6	≤7.5
31 years	≤6.6	≤7.6
32 years	≤6.7	≤7.7
33 years	≤6.8	≤7.7
34 years	≤6.8	≤7.8
35 years	≤6.9	≤7.9
36 years	≤6.9	≤7.9
37 years	≤7.0	≤8.0
38 years	≤7.0	≤8.1
39 years	≤7.0	≤8.2
40 years	≤7.1	≤8.2
41 years	≤7.1	≤8.3
42 years	≤7.2	≤8.4
43 years	≤7.3	≤8.5
44 years	≤7.4	≤8.6
45 years	≤7.4	≤8.7
46 years	≤7.5	≤8.8
47 years	≤7.6	≤8.9
48 years	≤7.6	≤9.0
49 years	≤7.7	≤9.1
50 years	≤7.7	≤9.2
51 years	≤7.8	≤9.3
52 years	≤7.8	≤9.4
53 years	≤7.9	≤9.5
54 years	≤8.0	≤9.6
55 years	≤8.1	≤9.7
56 years	≤8.1	≤9.7
57 years	≤8.2	≤9.8
58 years	≤8.3	≤9.8
59 years	≤8.3	≤9.8
60 years	≤8.3	≤9.9
61 years	≤8.3	≤9.9
62 years	≤8.4	≤9.9
63 years	≤8.4	≤10.0
64 years	≤8.4	≤10.0
65 years	≤8.4	≤10.0
66 years	≤8.5	≤10.1
67 years	≤8.5	≤10.1
68 years	≤8.5	≤10.1
69 years	≤8.5	≤10.2
70 years	≤8.5	≤10.2
71 years	≤8.6	≤10.2
72 years	≤8.6	≤10.2
73 years	≤8.5	≤10.1
74 years	≤8.5	≤10.1
75 years	≤8.6	≤10.1
76 years	≤8.6	≤10.0
77 years	≤8.6	≤10.0
78 years	≤8.6	≤10.0
79 years	≤8.6	≤10.0
80 years	≤8.7	≤9.9
81 years	≤8.7	≤9.9
82 years	≤8.7	≤9.9
83 years	≤8.7	≤9.9
84 years	≤8.7	≤9.9
85 years	≤8.6	≤9.8
86 years	≤8.5	≤9.8
87 years	≤8.4	≤9.7
88 years	≤8.3	≤9.7
89 years	≤8.1	≤9.5
90 years	≤7.9	≤9.4
91 years	≤7.6	≤9.2
92 years	≤7.4	≤9.0
93 years	≤7.1	≤8.8
94 years	≤7.0	≤8.7
= 95 years	≤6.9	≤8.6

For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Day(s) and Time(s) Performed

Monday through Thursday; 11 a.m.

Friday; 2 p.m.

CPT Code Information

83497

LOINC Code Information

Test ID	Test Order Name	Order LOINC Value
HIAA	5-Hydroxyindoleacetic Acid, U	1695-6

Result ID	Test Result Name	Result LOINC Value
9248	5-Hydroxyindoleacetic Acid, U	1695-6
TM35	Collection Duration	13362-9
VL33	Urine Volume	3167-4

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection.

Ambient	No
Refrigerate	OK
Frozen	OK
50% Acetic Acid	Preferred
Boric Acid	OK
Diazolidinyl Urea	No
6M Hydrochloric Acid	OK
6M Nitric Acid	OK
Sodium Carbonate	OK
Thymol	OK
Toluene	OK

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.

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Test Code LAB352 5-Hydroxyindoleacetic Acid, 24 Hour, Urine