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Test Code LAB1264 Rickettsial Disease Panel

Important Note

This test will no longer be available as of July 31, 2018. The recommended replacement test is either Mayo Test SFGP, FMTAG or QFP.

Additional Codes

Mayo Test Code: FRDP


Specimen Required


Draw blood in a plain red-top or serum gel tube(s). Spin down and send 2 mL of serum refrigerated.


Profile Information

Test ID Reporting Name Available Separately Always Performed
FRTGM R. Typhi IgG/IgM Reflex to Titers No Yes
FRMGM RMSF IgG/IgM Reflex to Titers No Yes
FQGI Q Fever IgG Phase I Screen No Yes
FQG2S Q Fever IgG Phase II Screen No Yes
FQMI Q Fever IgM Phase I Screen No Yes
FQM2S Q Fever IgM Phase II Screen No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
FRTG R. Typhi IgG Titer No No
FRTM R. Typhi IgM Titer No No
FRMFG RMSF IgG Titer No No
FRMFM RMSF IgM Titer No No
FQFG1 Q Fever IgG Phase I Titer No No
FQFG2 Q Fever IgG Phase II Titer No No
FQFM1 Q Fever IgM Phase I Titer No No
FQFM2 Q Fever IgM Phase II Titer No No

Testing Algorithm

If R. Typhi IgG is Detected - FRTG Rickettsia (Typhus Fever) IgG Titer will be performed at an additional charge.

If R. Typhi IgM is Detected - FRTM Rickettsia (Typhus Fever) IgM Titer will be performed at an additional charge.

If RMSF IgG is Detected - FRMFG Rickettsia (RMSF) IgG Titer will be performed at an additional charge.

If RMSF IgM is Detected - FRMFM Rickettsia (RMSF) IgM Titer will be performed at an additional charge.

If Q Fever IgG Phase I (FQGI) is Positive - FQFG1 Q Fever IgG Phase I Titer will be performed at an additional charge.

If Q Fever IgM Phase I (FQMI) is Positive - FQFG2 Q Fever IgM Phase I Titer will be performed at an additional charge.

If Q Fever IgG Phase II (FQG2S) is Positive - FQFM1 Q Fever IgG Phase II Titer will be performed at an additional charge.

If Q Fever IgM Phase II (FQM2S) is Positive - FQFM2 Q Fever IgM Phase II Titer will be performed at an additional charge.

Method Name

Immunofluorescence Assay (IFA)

Reporting Name

Rickettsial Disease Panel

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  7 days

Reject Due To

Hemolysis:

Mild OK, Gross Reject

Thawing:

NA

Lipemia:

Mild OK; Gross Reject

Icterus:

NA

Other:

NA

Reference Values

R. Typhi IgG/IgM  

RMSF IgG/IgM  

 

Reference Range:  Not Detected

 

Q Fever IgG/IgM Phase I/II Screens

 

Reference Range: Negative

    

Q Fever Antibody testing includes differentiation of antibodies to Phase I and Phase II antigenic variants. Coxiella burnetii, which causes Q Fever, undergoes transitions between Phase I and Phase II states. These phases are serologically distinguishable and useful in the serodiagnosis of acute and chronic disease.

      

In some cases, the ratio of titer of phase II to phase I may indicate the stage of the disease. A ratio of greater than 1 may indicate the acute stage; greater than or equal to 1, granulomatous hepatitis; and less than 1, the chronic stage or endocarditis.

      

As with other infectious diseases, IgM antibodies are the first to appear. Usually they are detectable for a few weeks or, at the most, for a few months. IgG antibodies appear somewhat later but can persist for years, even for life.

      

Although single phase II IgG titers of 1:256 or greater are considered evidence of acute C. burnetii disease, the best criterion for a dependable diagnosis is still the demonstration of a fourfold or higher increase in antibody titer between the acute and convalescent serum samples. 

Day(s) and Time(s) Performed

Monday through Friday

Performing Laboratory

Quest Diagnostics Infectious Disease

CPT Code Information

86638/x4 Q Fever

86757/x4 Rickettsia

86638/each Q Fever titer (if appropriate)

86757/each Rickettsia titer (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FRDP Rickettsial Disease Panel In Process

 

Result ID Test Result Name Result LOINC Value
Z3177 R. Typhi IgG 22488-1
Z3179 RMSF IgG 32999-5
FQGI Q Fever IgG Phase I Screen 32644-7
FQG2S Q Fever IgG Phase II Screen 31314-8
FQMI Q Fever IgM Phase I Screen 32645-4
FQM2S Q Fever IgM Phase II Screen 31315-5
Z3180 RMSF IgM 33000-1
Z3178 R. Typhi IgM 33001-9