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Test Code METAR Metanephrines, Fractionated, Random, Urine

Reporting Name

Metanephrines, Fract., Random, U

Useful For

A second-order screening test for the presumptive diagnosis of pheochromocytoma in patients with nonepisodic hypertension

 

Confirming positive plasma metanephrine results in patients with nonepisodic hypertension

Profile Information

Test ID Reporting Name Available Separately Always Performed
RCTU Creatinine Conc No Yes
METAU Metanephrines, Fractionated, U No Yes

Method Name

RCTU: Enzymatic Colorimetric Assay

METAU: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Stable Isotope Dilution Analysis

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Urine


Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Patient Preparation: Tricyclic antidepressants and labetalol and sotalol (beta blockers) may elevate levels of metanephrines. If clinically feasible, these medications should be discontinued at least 1 week before collection.

Collection Container/Tube: Clean, plastic urine collection container

Submission Container/Tube: Plastic urine tube (T068)

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Frozen (preferred) 14 days
  Ambient  7 days
  Refrigerated  7 days

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA

Reference Values

METANEPHRINE/CREATININE

Normotensives

0-2 years: 82-418 mcg/g creatinine

3-8 years: 65-332 mcg/g creatinine

9-12 years: 41-209 mcg/g creatinine

13-17 years: 30-154 mcg/g creatinine

≥18 years: 29-158 mcg/g creatinine

 

NORMETANEPHRINE/CREATININE

Males

Normotensives

0-2 years: 121-946 mcg/g creatinine

3-8 years: 92-718 mcg/g creatinine

9-12 years: 53-413 mcg/g creatinine

13-17 years: 37-286 mcg/g creatinine

18-29 years: 53-190 mcg/g creatinine

30-39 years: 60-216 mcg/g creatinine

40-49 years: 69-247 mcg/g creatinine

50-59 years: 78-282 mcg/g creatinine

60-69 years: 89-322 mcg/g creatinine

≥70 years: 102-367 mcg/g creatinine

Females

Normotensives

0-2 years: 121-946 mcg/g creatinine

3-8 years: 92-718 mcg/g creatinine

9-12 years: 53-413 mcg/g creatinine

13-17 years: 37-286 mcg/g creatinine

18-29 years: 81-330 mcg/g creatinine

30-39 years: 93-379 mcg/g creatinine

40-49 years: 107-436 mcg/g creatinine

50-59 years: 122-500 mcg/g creatinine

60-69 years: 141-574 mcg/g creatinine

≥70 years: 161-659 mcg/g creatinine

 

TOTAL METANEPHRINE/CREATININE

Males

Normotensives

0-2 years: 241-1,272 mcg/g creatinine

3-8 years: 186-980 mcg/g creatinine

9-12 years: 110-582 mcg/g creatinine

13-17 years: 78-412 mcg/g creatinine

18-29 years: 96-286 mcg/g creatinine

30-39 years: 106-316 mcg/g creatinine

40-49 years: 117-349 mcg/g creatinine

50-59 years: 130-386 mcg/g creatinine

60-69 years: 143-427 mcg/g creatinine

≥70 years: 159-472 mcg/g creatinine

Females

Normotensives

0-2 years: 241-1,272 mcg/g creatinine

3-8 years: 186-980 mcg/g creatinine

9-12 years: 110-582 mcg/g creatinine

13-17 years: 78-412 mcg/g creatinine

18-29 years: 131-467 mcg/g creatinine

30-39 years: 147-523 mcg/g creatinine

40-49 years: 164-585 mcg/g creatinine

50-59 years: 184-655 mcg/g creatinine

60-69 years: 206-733 mcg/g creatinine

≥70 years: 230-821 mcg/g creatinine

Day(s) and Time(s) Performed

Monday through Friday; 4 p.m.

CPT Code Information

83835

LOINC Code Information

Test ID Test Order Name Order LOINC Value
METAR Metanephrines, Fract., Random, U In Process

 

Result ID Test Result Name Result LOINC Value
21546 Metanephrine/Creatinine 35644-4
RCTU Creatinine Conc 2161-8
21547 Normetanephrine/Creatinine 44342-4
21548 Total Metanephrine/Creatinine 32655-3

Test Classification

This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request Form (T729) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/oncology-request-form.pdf)