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Test Code LAB3210 BCR/ABL, p190, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Assay

Additional Codes

Mayo Test Code: BA190

Reporting Name

BCR/ABL, p190, Quant, Monitor

Useful For

Monitoring response to therapy in patients with known e1/a2 bcr/abl (p190) fusion forms

Method Name

Quantitative Reverse Transcription-Polymerase Chain Reaction (RT-PCR)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Advisory Information

This test should not be used to screen for bcr/abl fusions at the time of diagnosis; BADX / BCR/ABL1, Qualitative, Diagnostic Assay should be ordered for that purpose.

Shipping Instructions

Refrigerate specimen must arrive within 5 days (120 hours of draw), and ambient specimens must arrive within 3 days (72 hours) of draw. Draw and package specimen as close to shipping time as possible.

Necessary Information

The following information is required:

1. Pertinent clinical history including if the patient has a diagnosis of chronic myelogenous leukemia or other bcr/abl-positive neoplasm

2. Date of collection

3. Specimen source (blood or bone marrow)

Specimen Required

Submit only 1 of the following specimens:


Specimen Type: Whole blood


Preferred: EDTA (lavender top)

Acceptable: ACD (yellow top)

Specimen Volume: 4 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

3. Label specimen as blood.


Specimen Type: Bone marrow


Preferred: EDTA (lavender top)

Acceptable: ACD (yellow top)

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix bone marrow.

2. Send specimen in original tube.

3. Label specimen as bone marrow.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Varies Refrigerated (preferred) 5 days
  Ambient  72 hours

Reject Due To


Mild OK; Gross reject






Moderately to severely clotted

Reference Values

The presence or absence of the BCR/ABL mRNA (bcr/abl) fusion form producing the p190 fusion protein is reported. If positive, the level is reported as the ratio of bcr/abl (p190) to abl with conversion to a percentage (ie, bcr/abl (p190) as a percentage of total abl).

Day(s) and Time(s) Performed

Monday through Friday a.m.

CPT Code Information

81207-BCR/ABL1 (t[9;22]) (eg, chronic myelogenous leukemia) translocation analysis; minor breakpoint, qualitative or quantitative

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BA190 BCR/ABL, p190, Quant, Monitor In Process


Result ID Test Result Name Result LOINC Value
39470 BCR/ABL p190 Result In Process
MP002 Specimen Type 31208-2
19765 Final Diagnosis: 34574-4

Secondary ID


Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.


1. Hematopathology Patient Information (T676) in Special Instructions

2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request Form (T726) with the specimen (