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Test Code L3AFP Alpha-Fetoprotein (AFP) L3% and Total, Hepatocellular Carcinoma Tumor Marker, Serum

Reporting Name

AFP-L3% and Total AFP, S

Useful For

Distinguishing between hepatocellular carcinoma and chronic liver disease


Monitoring individuals with hepatic cirrhosis from any etiology for progression to hepatocellular carcinoma


Surveillance for development of hepatocellular carcinoma in individuals with a positive family history of hepatic cancer


Surveillance for development of hepatocellular carcinoma in individuals within specific ethnic and gender groups who do not have hepatic cirrhosis, but have a confirmed diagnosis of chronic infection by hepatitis B acquired early in life including:

-African males above the age of 20

-Asian males above the age of 40

-Asian females above the age of 50

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 90 days
  Refrigerated  5 days

Reference Values


Day(s) and Time(s) Performed

Monday, Wednesday, Friday; 10 a.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
L3AFP AFP-L3% and Total AFP, S In Process


Result ID Test Result Name Result LOINC Value
TAFP Total AFP, S 1834-1
L3 %L3 42332-7
INT67 Interpretation No LOINC Needed

Reject Due To


Mild OK; Gross reject


Mild OK; Gross OK





Method Name

Isotachophoresis with Laser-Induced Fluorescence