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Test Code FNMR2 NMR LipoProfile w/IR Markers

Profile Information

Test ID Reporting Name Available Separately Always Performed
FLPDN LDL Particle Number No Yes
FLIPS Lipids No Yes
FLHP LDL and HDL Particles No Yes
FIRD Insulin Resistance/Diab. Risk No Yes
FIRSC Insulin Resistance Score No Yes

Method Name

Nuclear Magnetic Resonance (NMR)

Reporting Name

NMR LipoProfile w/IR Markers

Specimen Type

Varies


Specimen Required


Submit only one of the following specimens:

 

Serum

Draw blood in a plain red-top tube(s). (Serum gel tube is not acceptable.) Spin down and send 2 mL serum refrigerate in a plastic vial.

Note:    1. Patient should be fasting (12 – 14 hours)

            2. Specimen must be received at LabCorp within 6 days of collection.

            3. Label specimen appropriately (serum).

 

Plasma

Draw blood in a (lavender-top) EDTA tube(s). (Plasma gel tube is not acceptable.) Spin down and send 2 mL plasma refrigerate in a plastic vial.

Note:    1. Patient should be fasting (12 – 14 hours)

            2. Specimen must be received by LabCorp within 6 days of collection.

            3. Label specimen appropriately (plasma).


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Varies Refrigerated 6 days

Reject Due To

Hemolysis

Mild OK; Gross reject

Thawing

NA

Lipemia

NA

Icterus

NA

Other

Serum separator tube (SST), Plasma Separator tube (PST), frozen specimen, warm/room temperature specimen

Reference Values

LDL Particle Number

LDL-P <1000 nmol/L

Low:

<1000 nmol/L

Moderate:

1000 - 1299

Borderline-High:

1300 - 1599

High:

1600 - 2000

Very High:

>2000

 

Lipids

LDL-C

0 – 19 years

0 - 109 mg/dL

>19 years

0 - 99 mg/dL

 Optimal:

<100

 Above Optimal:

100 - 129

 Borderline:

130 - 159

 High:

160 - 189

 Very High:

>189

 

 

 Comment: LDL-C is inaccurate if patient is non-fasting.

 

HDL-C

>39 mg/dL

Triglycerides

 

 0 – 9 yrs:

0 - 74 mg/dL

 10 – 19 yrs:

0 - 89 mg/dL

 >19 years

0 - 149 mg/dL

 

Total Cholesterol

 0 – 19 yrs:

100 - 169 mg/dL

>19 years

100 - 199 mg/dL

 

LDL and HDL Particles

HDL-P (Total)

>or= 30.5 umol/L

Small LDL-P

<or= 527 nmol/L

LDL Size

>20.5 nm

 

PARTICLE CONCENTRATION AND SIZE

            <-- Lower CVD Risk                                           Higher CVD Risk-->

LDL AND HDL PARTICLES                    Percentile in Reference Population

HDL-P (total)

High

75th

50th

25th

Low

 

>34.9

34.9

30.5

26.7

<26.7

Small LDL-P

Low

25th

50th

75th

High

 

<117

117

527

839

>839

LDL Size           <-- Large (Pattern A) -->                         <-- Small (Pattern B) -->

 

23.0

20.6

20.5

19.0

 

 

Comment: Small LDL-P and LDL Size are associated with CVD risk, but not after LDL-P is taken into account.

 

These assays were developed and their performance characteristics determined by LipoScience. These assays not been cleared by the US Food and Drug Administration. The clinical utility of these laboratory values have not been fully established.

 

Insulin Resistance and Diabetes Risk

Large VLDL-P

<or= 2.7 nmol/L

Small LDL-P

<or= 527 nmol/L

Large HDL-P

>or = 4.8 umol/L

VLDL Size

<or= 46.6 nm

LDL Size

>or= 20.8 nm

HDL Size

>or= 9.2 nm

 

Insulin Resistance Score

LP-IR Score ≤ 45

 Comment: LP-IR Score is inaccurate if patient is non-fasting.

 

INSULIN RESISTANCE/DIABETES RISK MARKERS

            <--Insulin Sensitive                                                                    Insulin Resistant -->

                                                Percentile in Reference Population

Large VLDL-P

Low

25th

50th

75th

High

 

<0.9

0.9

2.7

6.9

>6.9

Small LDL-P

Low

25th

50th

75th

High

 

<117

117

527

839

>839

Large HDL-P

High

75th

50th

25th

Low

 

>7.3

7.3

4.8

3.1

<3.1

VLDL Size

Small

25th

50th

75th

Large

 

<42.4

42.4

46.6

52.5

>52.5

LDL Size

Large

75th

50th

25th

Small

 

>21.2

21.2

20.8

20.4

<20.4

HDL Size

Large

75th

50th

25th

Small

 

>9.6

9.6

9.2

8.9

<8.9

Insulin Resistance Score

LP-IR SCORE

Low

25th

50th

75th

High

 

<27

27

45

63

>63

 

The LP-IR score is a laboratory developed index that has been associated with insulin resistance and diabetes risk and should be used as one component of a physician's clinical assessment. Neither the LP-IR score nor the subclasses listed above have been cleared by the US Food and Drug Administration.

Day(s) and Time(s) Performed

Monday through Friday

Performing Laboratory

LabCorp Burlington

CPT Code Information

80061

83704

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FNMR2 NMR LipoProfile w/IR Markers In Process

 

Result ID Test Result Name Result LOINC Value
Z4454 LP-IR Score 62255-5
Z4448 Large VLDL-P 43728-5
Z4441 LDL-C 13457-7
Z4445 HDL-P (Total) 49748-7
Z4440 LDL-P 54434-6
Z4446 Small LDL-P 43727-7
Z4442 HDL-C 2085-9
Z4449 Small LDL-P 43727-7
Z4450 Large HDL-P 43729-3
Z4443 Triglycerides 2571-8
Z4447 LDL Size 17782-4
Z4444 Cholesterol, Total 2093-3
Z4451 VLDL Size 62254-8
Z4452 LDL Size 17782-4
Z4453 HDL Size 62253-0