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Test Code FLFFT Liver Fibrosis, Fibro Test-ActiTest Panel

Method Name

Nephelometry and Spectrophotometry

Reporting Name

Liver Fibrosis, FibroTest

Specimen Type

Serum


Specimen Required


Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 3.5 mL of serum frozen in a plastic screw-capped vial.

 

Note:    1. Overnight fast is preferred.

            2. Not available for patients less than 2 years of age.


Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 5 days
  Refrigerated  5 days
  Ambient  24 hours

Reject Due To

Hemolysis

Mild Ok; Gross reject

Thawing

Warm reject; Cold OK

Lipemia

Mild Ok; Gross reject

Icterus

NA

Other

Patient <2 years old; QNS for one or more analytes

Reference Values

Test

Reference Range

Fibrosis Score

No reference range available

Fibrosis Stage

No reference range available

Fibrosis Interpretation

FibroTest Score

Metavir Score

 

0.00-0.21

F0 no fibrosis

 

0.22-0.27

F0-F1

 

0.28-0.31

F1 minimal fibrosis

 

0.32-0.48

F1-F2

 

0.49-0.58

F2 moderate fibrosis

 

0.59-0.72

F3 advanced fibrosis

 

0.73-0.74

F3-F4

 

0.75-1.00

F4 severe fibrosis

Necroinflammat Act Score

No reference range available

Necroinflammat Act Grade

No reference range available

Necroinflammat Interp

ActiTest Score

Metavir Score

0.00-0.17

A0 no activity

0.18-0.29

A0-A1

0.30-0.36

A1 minimal activity

0.37-0.52

A1-A2

0.53-0.60

A2 significant activity

0.61-0.62

A2-A3

0.63-1.00

A3 severe activity

Alpha-2-Macroglobins

<18 Years: Not established

≥18 Years: 106-279 mg/dL

Haptoglobin

<18 Years: Not established

≥18 Years: 43-212 mg/dL

Apolioprotein A-1

Males:

<18 Years: Not established

≥18 Years: 94-176 mg/dL

Females:

<18 Years: Not established

≥18 Years: 101-198 mg/dL

Total Bilirubin

2-9 Years: 0.2-0.8 mg/dL

10-19 Years: 0.2-1.1 mg/dL

≥20 Years: 0.2-1.2 mg/dL

GGT

Males:

2-12 Years: 3-22 U/L

13-15 Years: 8-32 U/L

16-19 Years: 9-31 U/L

20-29 Years: 3-70 U/L

30-39 Years: 3-90 U/L

40-54 Years: 3-95 U/L

55-59 Years: 3-85 U/L

≥60 Years: 3-70 U/L

Females:

2-12 Years: 3-22 U/L

13-15 Years: 7-18 U/L

16-19 Years: 6-26 U/L

20-29 Years: 3-40 U/L

30-39 Years: 3-50 U/L

40-49 Years: 3-55 U/L

50-59 Years: 3-70 U/L

≥60 Years: 3-65 U/L

Alanine Aminotransferase (ALT)

Males:

2-3 Years: 5-30 U/L

4-12 Years: 8-30 U/L

13-15 Years: 7-32 U/L

16-19 Years: 8-46 U/L

≥20 Years: 9-46 U/L

Females:

2-3 Years: 5-30 U/L

4-12 Years: 8-24 U/L

13-15 Years: 5-32 U/L

16-19 Years: 5-32 U/L

≥20 Years: 6-29 U/L

 

The reliability of results is dependent on compliance with the pre-analytical and analytical conditions recommended by BioPredictive. The Tests have to be deferred for: acute hemolysis, acute hepatitis, acute inflammation, extra hepatic cholestasis. The advice of a specialist should be sought for interpretation in chronic hemolysis and Gilbert's syndrome. The Test interpretation is not validated in liver transplant patients. Isolated extreme values of one of the components should lead to caution in interpreting the results. In case of discordance between a biopsy result and a Test, it is recommended to seek the advice of a specialist. The cause of these discordances could be due to a flaw of the Test or to a flaw in the biopsy: i.e. a liver biopsy has a 33% variability rate for one fibrosis stage. FibroTest is interpretable for chronic hepatitis B and C, alcoholic and non-alcoholic steatosis. ActiTest is interpretable for chronic hepatitis B and C.

Day(s) and Time(s) Performed

Tuesday through Saturday

Performing Laboratory

Quest Diagnostics Nichols Institute

Test Classification

The performance characteristics have been determined by Quest Diagnostics Nichols Institute, San Juan Capistrano. It has not been cleared or approved by the U.S. Food and Drug Administration. Performance characteristics refer to the analytical performance of the test.

CPT Code Information

82172

82247

82977

83010

83883

84460

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FLFFT Liver Fibrosis, FibroTest In Process

 

Result ID Test Result Name Result LOINC Value
Z4458 Fibrosis Score 48795-9
Z4459 Fibrosis Stage 48794-2
Z4460 Fibrosis Interpretation In Process
Z4461 Necroinflammat Act Score 48792-6
Z4462 Necroinflammat Act Grade 48793-4
Z4463 Necroinflammat Interp In Process
Z4464 Alpha-2-Macroglobulin 1835-8
Z4465 Haptoglobin 4542-7
Z4466 Apolipoprotein A1 1869-7
Z4467 Total Bilirubin 1975-2
Z4468 GGT 2324-2
Z4469 ALT 1742-6
Z4470 Reference ID 30896-5
Z4471 Footnote 62364-5