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Test Code AFP Alpha-Fetoprotein (AFP) Tumor Marker, Serum

Reporting Name

Alpha-Fetoprotein, Tumor Marker, S

Useful For

The follow-up management of patients undergoing cancer therapy, especially for testicular and ovarian tumors and for hepatocellular carcinoma


Often used in conjunction with human chorionic gonadotropin(2)

Method Name

Immunoenzymatic Assay

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.6 mL

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  90 days

Reject Due To


Mild OK; Gross reject


Mild OK; Gross OK






Special Instructions

Reference Values

<6.0 ng/mL

Reference values are for nonpregnant subjects only; fetal production of AFP elevates values in pregnant women.

Range for newborns is not available, but concentrations over 100,000 ng/mL have been reported in normal newborns, and the values rapidly decline in the first 6 months of life.(See literature reference: Ped Res 1981;15:50-52) For further interpretive information, see Alpha-Fetoprotein (AFP) in Special Instructions.

Serum markers are not specific for malignancy, and values may vary by method.

Day(s) and Time(s) Performed

Monday through Friday; 5 a.m.-12 a.m.

Saturday; 6 a.m.-6 p.m.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
AFP Alpha-Fetoprotein, Tumor Marker, S 53962-7


Result ID Test Result Name Result LOINC Value
AFP Alpha-Fetoprotein, Tumor Marker, S 53962-7

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.


If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

General Request Form (T239) (

Oncology Test Request Form (T729) (